Bronopol

SCA endorses products with the Allergy Certified logo, that do not contain bronopol. Considered a mild to moderate toxic chemicals by the Toxicology Data Network “Irritants may cause swelling, redness, and pain at any site, especially at mucous membranes. The mouth, nose, and eyes are commonly affected. After inhalation, cough, tachypnea, and wheezing are common. With ingestion, nausea, vomiting, and diarrhea are common.” - www.toxnet.nlm.nih.gov

“A total of 8149 patients were patch tested with the preservative Bronopol in 7 European contact clinics. The majority of patients were investigated in London. Reactivity was low, with a total of 10 irritant (0.12%) and 38 allergic reactions (0.47%). In only 17 cases (0.21%) was the patch test reaction to Bronopol considered to be of current or past clinical relevance. Based on these figures, the present sensitization rate to Bronopol in Europe seems to be quite low, which may be related to its less frequent use as a preservative in cosmetics and medicaments in comparison to parabens or isothiazolinones.” -www.toxnet.nlm.nih.gov

CLASSIFICATION

CAS No: 52-51-7 - Key Issues "Synonym(s): 2-BROMO-2-NITROPROPANE-1,3-DIOL, 1,3-PROPANEDIOL, 2-BROMO-2-NITRO-; 1,3PROPANEDIOL, 2BROMO2NITRO; 2-BROMO-2-NITRO- 1,3-PROPANEDIOL; BRONOPOL; 2-BROMO-2-NITRO-1,3-PROPANEDIOL; 2-BROMO-2-NITROPROPAN-1,3-DIOL; 2-BRONOPOL; BETA-BROMO-BETA-NITROTRIMETHYLENEGLYCOL; BRONIDIOL; BRONOCOT; BRONOPOL" - EWG

HOW IS IT USED?

Commonly used in colour cosmetics, liquid hair and baby care products, hand sanitisers, cosmetics, bleaching agents, adhesives, odour agents, topical medical creams, paint and carpets, nail products and all kinds of household cleaning agents.

  • Bronopol is a known formaldehyde releaser in cosmetics, PSIC.

  • NICNAS not restricted for use. Tier I assessment indicated that it needed further investigation. Tier II assessment November 2014.

  • EU Cosmetic Directive 76/768/EEC Annex VI Part 1, List of preservatives allowed (at up to 0.1%);

  • New Zealand Cosmetic Products Group Standard—Schedule 7: Preservatives cosmetic products may contain with restrictions;

  • Health Canada List of prohibited and restricted cosmetic ingredients (The Cosmetic Ingredient ‘Hotlist’)—Permitted at concentrations equal to or less than 0.1%. Not permitted in formulations that contain amines or amides; and

  • US Cosmetic Ingredient Review (CIR) Cosmetic ingredients found safe, with qualifications—should not be used in cosmetic products in which N-nitroso compounds can be formed.

RESEARCH - WHAT DO EXPERTS SAY:

  • "Bronopol allergic contact dermatitis. Bronopol (2-bromo-2-nitropropane-1, 3-diol) is an antimicrobial compound widely used as a preservative, primarily in cosmetic formulations. Analysis of patch tests performed on our patients revealed an incidence of 12.5% relevant positive results to 0.5% and/or 0.25% bronopol." - NCBI

  • Bronopol is found in an array of household products from cleaning agents to personal care products including: "Toiletries and Cosmetics; Blushers, Cleansing lotions, Creams, Eyebrow pencils, Formaldehyde releaser, Foundations, Hair conditioners, Hair dressings, Humidifiers, Mascara, Moisturizers, Shampoos, Deodorants

Washing Detergents." -ContactDermatitisInstitute.com

“Formaldehyde is a naturally occurring substance made of carbon, hydrogen and oxygen. Humans produce about 1.5 ounces of formaldehyde a day as a normal part of our metabolism. Inhaled formaldehyde is rapidly metabolized and ultimately converted to carbon dioxide and exhaled. Formaldehyde does not accumulate in the body.” - download the fact sheet by AmericanChemistry.com

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Amina Kitching